[A,D,G: Obj.x5, B,E,H: Obj.x 10, C,F,I: Obj.x20]

Figure 6: Immunohistochemical labeling of SERPINA3. A-C: Normal cortex reveals labeling of cortical ribbon in synaptic pattern (A). The neurons with dendritic processes in grey matter (C) and branching fibrous astrocytes in white matter are labeled (B).D-F: In cases of TBM, intense labeling of cortical ribbon is seen (A), concentrating around exudates in meninges (E, asterix) and in neurons with dendritic arborization (F). Note dense labeling of inflammatory cells in exudates (E, asterix) G-I: In cases of TBM with HIV, the labeling of cortical ribbon (G), neurons (I) and glial cells close to inflammatory exudates in subarachnoid space (H, asterix) is more intense than in TBM alone. In addition, a few glial shrubs intensely labeled are found in the cortical ribbon (I) unlike in cases of TBM without co-infection with HIV.