S.No Gene Symbol Protein Name Description Fold change
1 TYMP Thymidine phosphorylase precursor It promotes in vivo angiogenesis. It also stimulates the growth and migration of endothelial cells. 33.9
2 SLAMF8 SLAM family member 8 precursor It is involved in lymphocyte activation. 33.6
3 SERPINA3 Alpha-1-antichymotrypsin precursor It functions as an acute phase protein, increasing in plasma concentration in response to trauma and infection. 29.8
4 CIITA MHC class II transactivator Its functions as a positive regulator of class II major histocompatibility complex gene transcription. 28.7
5 CHI3L1 Chitinase-3-like protein 1 precursor It is involved in inflammatory processes and tissue remodeling. 27.9
6 IL4I1 Interleukin 4 induced 1 It shares some similarity with L-amino acid oxidase. It is said to be involved in the catalysis and binding of the flavin adenine dinucleotide cofactor. 25.1
7 C4B Complement C4-B preproprotein It is involved in the classical activation pathway. Following cleavage and trimerization, it provides a surface for interaction between the antigen-antibody complex and other complement factors. 14.9
8 IL21R Interleukin-21 receptor precursor It acts as receptor for the cytokine Interleukin-21. It is involved in lymphocyte differentiation and proliferation. 13.8
9 TCIRG1 V-type proton ATPase 116 kDa subunit a isoform 3 It is involved in the process of intracellular organelle acidification in eukaryotes. 12.7
10 IFI30 gGamma-interferon-inducible lysosomal thiol reductase preproprotein This enzyme is involved in MHC class II-restricted antigen processing. 12.0
Table 1: A partial list of upregulated genes in Tuberculous Meningitis co-infected with HIV.