| S.No |
Gene Symbol |
Protein Name |
Description |
Fold change |
| 1 |
PCMT1 |
Protein-L-isoaspartate (D-aspartate) O-methyltransferase |
It is a protein repair enzyme involved in the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form |
20.7 |
| 2 |
FBXW7 |
F-box and WD repeat domain containing 7 |
It is one of the four subunits of SCF ubiquitin protein ligase complex and is involved in phosphorylation-dependent ubiquitination |
18.7 |
| 3 |
S1PR1 |
Sphingosine-1-phosphate receptor 1 |
It plays a role in the differentiation of endothelial cells and cell-cell adhesion. |
15.6 |
| 4 |
HSPA8 |
Heat shock 70kDa protein 8 |
It belongs to the HSP70 family and is implicated in protein folding. It is also regulates the transport of membrane components through the cell by acting as an ATPase. |
13.9 |
| 5 |
USP3 |
Ubiquitin specific peptidase 3 |
It is a deubiquinating enzyme which deubiquinates H2A/H2B and is implicated in maintaining genome integrity. Knocking out this gene results in a delay in the S-phase progression of the cell cycle and accumulation of DNA breaks. |
13.0 |
| 6 |
SCG3 |
Secretogranin III |
It belongs to a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. The function of this protein is unknown. However, some granins may play a role in protein sorting and proteolytic processing of prohormones. |
12.2 |
| 7 |
CLK4 |
DC-like kinase 4 |
It is thought to regulate alternative splicing by interacting and phosphorylating serine and arginine rich proteins which are known to play an important role in the formation of spliceosomes. |
12.5 |
| 8 |
RAB1A |
RAB1A, member RAS oncogene family |
It belongs to the Ras family of GTPases and is implicated in the regulation of vesicular traffic from the endoplasmic reticulum to the golgi apparatus. |
11.0 |
| 9 |
SRP68 |
Signal recognition particle 68kDa |
It is a component of the signal recognition peptide complex, which transport secreted and membrane proteins to the endoplasmic reticulum for processing. |
9.8 |
| 10 |
EIF4EBP2 |
Eukaryotic translation initiation factor 4E binding protein 2 |
It is a member of the eukaryotic translation initiation factor 4E binding protein family which can bind eIF4E and inhibit translation initiation. |
8 |
