Epistatic Model 1 MOI gene1 D D R R gene2 D R D R gene1 gene2 Risk (¥) Risk (¥) Risk (¥) Risk (¥) AA BB 1 1 1 1 AA Bb Φb 1 Φb 1 AA bB Φb 1 Φb 1 AA bb Φb Φb Φb Φb Aa BB Φa Φa 1 1 Aa Bb Φa Φa Φv 1 Aa bB Φa Φa Φb 1 Aa bb Φa Φa Φb Φb aA BB Φa Φa 1 1 aA Bb Φa Φa Φb 1 aA bB Φa Φa Φb 1 aA bb Φa Φa Φb Φb aa BB Φa Φa Φa Φa aa Bb Φa Φa Φa Φa aa bB Φa Φa Φa Φa aa bb Φa Φa Φa Φa a = risk allele for gene1 A = allele without risk for gene1 b = risk allele for gene2 B = allele without risk for gene2

Table 2: Epistatic Model 1 depicted in terms of risk associated with various genotype combination.