Figure 1: Flowchart of the whole process conducted in this study. Representation of the whole process involved in the discovery of new biomarkers as simulated in this study. The “truth” left part of the figure corresponds to the simulation settings representing the global population. A total of p=1000 variables were under study, among whom p0 were under the null hypothesis H0 of no association with survival, and p1=20 under the alternative hypothesis. The right part of the figure corresponds to the identification and validation steps occurring in “omic” studies. R variables are selected on the identification set, and then validated in 50 distinct validation sets.