| Row |
Gene Name |
Cancer Tissue & Disease Names |
Gene Position on Human Genome |
Hotspot Position on cDNA |
Number of motif |
| Hot-spot |
Cold-spot |
| 1 |
PIK3CA |
large intestine, breast, endometrium |
Chromosome 3: 180,349,005-180,435,189 forward strand |
c.3140A>G |
3 |
1 |
| 2 |
APC |
large intestine, Stomach |
Chromosome 5: 112,101,483-112,209,834 forward strand |
c.4348C>T |
2 |
1 |
| 3 |
CDKN2A |
haematopoietic and lymphoid tissue, central nervous system, lung |
Chromosome 9: 21,957,751-21,984,490 reverse strand |
c.238C>T |
2 |
1 |
| 4 |
ATM |
haematopoietic and lymphoid tissue |
Chromosome 11: 107,598,769-107,745,036 forward strand. |
c.9023G>A |
3 |
2 |
| 5 |
RB1 |
Lung, eye |
Chromosome 13: 47,775,884-47,954,027 forward strand. |
c.958C>T |
0 |
2 |
| 6 |
VHL |
kidney |
Chromosome 3: 10,158,319-10,168,744 forward strand |
c.241C>T |
1 |
0 |
| 7 |
PTEN |
Endometrium, glioma, breast |
Chromosome 10: 89,613,175-89,718,511 forward strand |
c.388C>T |
4 |
0 |
| 8 |
FLT3 |
haematopoietic and lymphoid tissue |
Chromosome 13: 28576811:28675329:1 |
c.2503G>T |
1 |
0 |
| 9 |
MSH6 |
central nervous system, large intestine, stomach |
Chromosome 7: 48009621:48034692:1 |
c.3656C>T |
2 |
0 |
| 10 |
SMARCB1 |
soft tissue, central nervous system |
Chromosome 22: 24,129,150-24,176,701 forward strand. |
c.601C>T |
0 |
1 |
| 11 |
ALK |
autonomic ganglia |
Chromosome 2: 29,415,640-30,144,432 |
c.3824G>A |
0 |
1 |
| 12 |
CTNNB1 |
Liver, soft tissue |
Chromosome 3: 41,236,328-41,281,939 forward strand. |
c.121A>G & c.134C>T |
4 |
2 |
| 13 |
FGFR3 |
Achondroplasia, Skin, Urinary tract |
Chromosome 4: 1,795,560-1,810,598 |
c.746C>G |
3 |
0 |
| 14 |
CdK6 |
Skin |
Chromosome 7: 92,072,175-92,301,148 reverse strand. |
c.588C>T |
0 |
3 |
| 15 |
PDGFRA |
soft tissue, stomach |
Chromosome 4: 55,095,264-55,164,412 forward strand. |
c.2525A>T |
0 |
0 |
| 16 |
JAK2 |
haematopoietic and lymphoid tissue |
Chromosome 17: 7,512,445-7,531,642 reverse strand. |
c.1849G>T |
2 |
1 |
| 17 |
KIT |
haematopoietic and lymphoid tissue, soft tissue |
Chromosome 4: 55,524,095-55,606,879 forward strand. |
c.2447A>T |
5 |
0 |
| 18 |
MAP2K4 |
urinary tract, testis |
Chromosome 17: 11,864,866-11,987,865 forward strand. |
c.551C>T |
2 |
0 |
| 19 |
RET |
Thyroid, adrenal gland |
Chromosome 10: 42,892,523-42,945,805 forward strand. |
c.2753T>C |
0 |
0 |
| 20 |
P53 |
Breast, Large intestine, Upper aerodigestive tract |
Chromosome 17: 7572927-7579912 forward strand. |
c.743G>A |
2 |
0 |
|
