Protein Name Gene symbol PMID MAPK (pERK) Pathway Fascin FSCN1 20502940 Galectin-7 LGALS7 21289092 Lumican LUM 23154825 Serpin H1 SERPINH1 20188343 Guanine nucleotide-binding protein subunit beta-2-like 1 GNB2L1 22240482 Collagen alpha-2(I) chain COL1A2 22131293 UDP-glucose 6-dehydrogenase UGDH 14505572 Metalloproteinase inhibitor 1 TIMP1 23555182 Carboxypeptidase E OS CPE 22824791 Hepatoma-derived growth factor-related protein 3 HDGFRP3 22490522 Ras-related protein Rab- RAB7A 19372461 ATP synthase subunit e, mitochondrial OS ATP5I 11939412 Chromogranin-A OS CHGA 10197763 Galectin-3-binding protein LGALS3BP 22389450 Peroxiredoxin-6 PRDX6 21346153 Stress-70 protein, mitochondrial HSPA9 12646231 Annexin A2 OS ANXA2 22040021 Peroxiredoxin-1 PRDX1 23602274 RasGAP-like with IQ motifs IQGAP1 23603816 Tripeptidyl-peptidase 1 TPP1 22101936 Filamin-A FLNA 22203038 Apoptosis FACT complex subunit SSRP1 SSRP1 16498457 Apoptosis-inducing factor 1, mitochondrial OS AIFM1 16636662 Cytochrome c oxidase subunit 6C COX6C 22860893 Diablo homolog, mitochondrial DIABLO 10972280 Eukaryotic translation initiation factor 3 subunit B EIF3B 22234522 Glutaredoxin-1 GLRX 17185628 Glutathione peroxidase 3 GPX3 22461624 Heterogeneous nuclear ribonucleoprotein U HNRNPU 20101230 Mitochondrial carrier homolog 2 MTCH2 15899861 Profilin-1 PFN1 23331014 Rho GDP-dissociation inhibitor 1 ARHGDIA 19077262 Sorcin SRI 22052463 Very long chain acyl-CoA dehydrogenase, mitochondrial ACADVL 9680378 Polyadenylate-binding protein 2 PABPN1 22519734 Galectin-7 LGALS7 21289092 DNA replication licensing factor MCM3 MCM3 10495426 Annexin A2 OS ANXA2 22040021

Protein Name Gene symbol PMID PI3K/Akt/mTOR Pathway Basal cell adhesion molecule OS BCAM 23160466 Peroxiredoxin-1 PRDX1 19941984 N(G),N(G)-dimethylarginine dimethylaminohydrolase1 DDAH1 21212404 Proliferating cell nuclear antigen PCNA 23298485 Filamin-A FLNA 22203038 Aldo-keto reductase family 1 member C3 OS AKR1C3 18508192 ATP-citrate synthase OS ACLY 18922930 Stathmin STMN1 21683992 Serum amyloid P-component APCS 23182717 UDP-glucose 6-dehydrogenase UGDH 14505572 Keratin, type II cytoskeletal 8 KRT8 23449973 Metalloproteinase inhibitor 1 TIMP1 23555182 Collagen alpha-1(VI) chain COL6A1 11279127 Collagen alpha-3(VI) chain COL6A3 11279127 Heterogeneous nuclear ribonucleoprotein F HNRNPF     21157483 L-lactate dehydrogenase B chain LDHB 21199794 Poly [ADP-ribose] polymerase 1 PARP1 17525332 Small nuclear ribonucleoprotein E SNRPE 23358685 Guanine nucleotide-binding protein subunit beta-2-like 1 GNB2L1 22240482 Wnt Pathway Carboxypeptidase E OS CPE 22824791 ATP-dependent RNA helicase DDX3X DDX3X 23413191 High mobility group protein B2* HMGB2 19805379 Guanine nucleotide-binding protein subunit beta-2-like 1 GNB2L1 22240482 Glutathione S-transferase Mu 3 GSTM3 20118494 Methyl-CpG-binding protein 2 MECP2 23200852 Moesin MSN 23221384 Ras GTPase-activating protein-binding protein 1 G3BP1 21652632 Annexin A1 OS ANXA1 21383699

Table 2: Proteins identified in PI3K/Akt/mTOR, p38 MAPK, Apoptosis, and wnt signaling pathways. The protein name, gene symbol, accession number, and PubMed identifier (PMID) for the journal linking the protein to a particular signaling pathway are listed for each protein.