Variable Number of cases pfetin positive pfetin negative Correlation (pfetin) χ2 P value Disease-free survival Multivariate analysis of disease-free survival by Cox regression Rate (%) Log-rank (P value) P value Relative risk 95% confidence interval Age                   <60 34 20 14 0.224 76.47 0.4463 ≥60 37 26 11 81.08 Sex                   F 26 19 7 0.197 88.46 0.2402 M 45 27 18 73.33 Site                   Stomach 52 33 19 0.571 78.85   Small intestine 16 13 3 81.25 0.7867 Other 3 0 3 66.67   Histology                   Spindle 62 42 20 0.225 80.65   Epithelioid 7 3 4 71.43 0.9707 Mixed 2 1 1 50   Size (cm)                   <5 44 33 11 0.006 88.64 0.0028 0.356 0.54 0.146-1.999 5–15 24 13 11 70.83 ≥15 3 0 3 0 Necrosis                   Present 16 9 7 0.299 75 0.4581       Absent 55 37 18 80 Risk classificationa                   Low 50 36 14 0.028 92 <0.0001 0.028 2.696 1.116-6.514 Intermediate 6 4 2 83.33 High 15 6 9 33.33 Recurrence/Metastasis                   Present 15 2 13 <0.0001           Absent 56 44 12           pfetin                   Positive 46 46 0   95.65 <0.0001 0.015 0.126 0.024-0.664 Negative 25 0 25 48 aRisk classification accrding to Miettinen’s risk classification

Table 1: Univariate and Multivariate analysis and the relationship between clinicopathologic variables and pfetin expression of the 71 GIST cases.