Interaction Energy (kcal/mol) EC Cln1 (flip) - Cdc28 - 745.2 0.50 Cln1 (flop) - Cdc28 - 836.1 0.54 Cln2 (flip) - Cdc28 - 672.8 0.51 Cln2 (flop) - Cdc28 - 875.7 0.54

Table 1: Interaction Energy and Electrostatistic Complementarity of Cln1-Cdc28, and Cln2-Cdc28.