ID_IPI Up-Regulated Protein Name ID_IPI Down Regulated Protein Name IPI00003377 Isoform 1 of Splicing factor, arginine/serine-rich 7 IPI00001580 Isoform 1 of FYVE and coiled-coil domain-containing protein 1 IPI00009407 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 IPI00003783 Dual specificity mitogen-activated protein kinase kinase 2 IPI00010271 Isoform A of Ras-related C3 botulinum toxin substrate 1 precursor IPI00005162 Actin-related protein 2/3 complex subunit 3 IPI00011118 Ribonucleoside-diphosphate reductase M2 subunit IPI00007694 Isoform 1 of Protein phosphatase methylesterase 1 IPI00012750 40S ribosomal protein S25 IPI00009841 CDNA FLJ31747 fis, clone NT2RI2007377, highly similar to RNA-BINDING PROTEIN EWS IPI00015954 GTP-binding protein SAR1a IPI00011107 Isocitrate dehydrogenase [NADP], mitochondrial precursor IPI00021840 40S ribosomal protein S6 IPI00011578 Isoform 1 of Neuroplastin precursor IPI00023048 Elongation factor 1-delta IPI00011692 Involucrin IPI00023101 Protein RCD1 homolog IPI00013933 Isoform DPI of Desmoplakin IPI00056334 protein kinase C, delta binding protein IPI00025084 Calpain small subunit 1 IPI00215768 Glutamate--cysteine ligase catalytic subunit IPI00216318 Isoform Long of 14-3-3 protein beta/alpha IPI00219365 Moesin IPI00219301 Myristoylated alanine-rich C-kinase substrate IPI00221088 40S ribosomal protein S9 IPI00219526 Isoform 1 of Phosphoglucomutase-1 IPI00290279 Isoform Long of Adenosine kinase IPI00240675 programmed cell death 4 isoform 2 IPI00293260 Isoform 1 of DnaJ homolog subfamily C member 10 precursor IPI00293464 DNA damage-binding protein 1 IPI00295992 Isoform 2 of ATPase family AAA domain-containing protein 3A IPI00307200 Switch-associated protein 70 IPI00329629 DnaJ homolog subfamily C member 7 IPI00412880 Isoform 1 of Histone-arginine methyltransferase CARM1 IPI00384444 Keratin, type I cytoskeletal 14 IPI00001580 Isoform 1 of FYVE and coiled-coil domain-containing protein 1 IPI00414676 Heat shock protein HSP 90-beta IPI00003783 Dual specificity mitogen-activated protein kinase kinase 2 IPI00449049 Poly [ADP-ribose] polymerase 1 IPI00005162 Actin-related protein 2/3 complex subunit 3     IPI00007694 Isoform 1 of Protein phosphatase methylesterase 1     IPI00009841 CDNA FLJ31747 fis, clone NT2RI2007377, highly similar to RNA-BINDING PROTEIN EWS     IPI00011107 Isocitrate dehydrogenase [NADP], mitochondrial precursor     IPI00011578 Isoform 1 of Neuroplastin precursor     IPI00011692 Involucrin     IPI00013933 Isoform DPI of Desmoplakin     IPI00025084 Calpain small subunit 1     IPI00216318 Isoform Long of 14-3-3 protein beta/alpha     IPI00219301 Myristoylated alanine-rich C-kinase substrate     IPI00219526 Isoform 1 of Phosphoglucomutase-1     IPI00240675 programmed cell death 4 isoform 2     IPI00293464 DNA damage-binding protein 1     IPI00307200 Switch-associated protein 70     IPI00412880 Isoform 1 of Histone-arginine methyltransferase CARM1

Protein annotation was performed using DAVID with proteins annotated with skin tissue as the filter, and two clusters of 20 up-regulated and 34 down-regulated proteins were obtained

Table 2: Arsenic regulated proteins annotated with the skin tissue.