CLUSTERID GO_TERM GO_ID ID_IPI Protein Name CLUSTER1_Down acetyl-CoA metabolic process GO:0006084 IPI00096066 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursor CLUSTER1_Down acetyl-CoA metabolic process GO:0006084 IPI00294911 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor CLUSTER1_Down cellular aldehyde metabolic process GO:0006081 IPI00011107 Isocitrate dehydrogenase [NADP], mitochondrial precursor CLUSTER1_Down coenzyme metabolic process GO:0006732 IPI00184821 Bifunctional coenzyme A synthase CLUSTER1_Down DNA metabolic process GO:0006259 IPI00013871 Ribonucleoside-diphosphate reductase large subunit CLUSTER1_Down DNA metabolic process GO:0006259 IPI00018349 DNA replication licensing factor MCM4 CLUSTER1_Down DNA metabolic process GO:0006259 IPI00184330 DNA replication licensing factor MCM2 CLUSTER1_Down fatty acid metabolic process GO:0006631 IPI00024993 Enoyl-CoA hydratase, mitochondrial precursor CLUSTER1_Down membrane lipid metabolic process GO:0006643 IPI00005745 Serine palmitoyltransferase 1 CLUSTER1_Down monosaccharide metabolic process GO:0005996 IPI00550364 Phosphoglucomutase-2 CLUSTER1_Down monosaccharide metabolic process GO:0005996 IPI00479186 Isoform M2 of Pyruvate kinase isozymes M1/M2 CLUSTER1_Down monosaccharide metabolic process GO:0005996 IPI00219526 Isoform 1 of Phosphoglucomutase-1 CLUSTER1_Down monosaccharide metabolic process GO:0005996 IPI00073772 Fructose-1,6-bisphosphatase 1 CLUSTER1_Down monosaccharide metabolic process GO:0005996 IPI00063408 dehydrogenase E1 and transketolase domain containing protein 1 CLUSTER1_Down nucleoside metabolic process GO:0009116 IPI00219617 Isoform 1 of Ribose-phosphate pyrophosphokinase 2 CLUSTER1_Down purine nucleobase metabolic process GO:0006144 IPI00025273 Isoform Long of Trifunctional purine biosynthetic protein adenosine-3 CLUSTER1_Down purine nucleobase metabolic process GO:0006144 IPI00029079 GMP synthase CLUSTER1_Down regulation of nucleotide metabolic process GO:0006140 IPI00220578 Guanine nucleotide-binding protein G CLUSTER1_Down retinoid metabolic process GO:0001523 IPI00026663 Aldehyde dehydrogenase 1A3 CLUSTER1_Down tRNA metabolic process GO:0006399 IPI00004860 Isoform Complexed of Arginyl-tRNA synthetase, cytoplasmic CLUSTER1_Down tRNA metabolic process GO:0006399 IPI00216951 Aspartyl-tRNA synthetase, cytoplasmic CLUSTER1_Down very long-chain fatty acid metabolic process GO:0000038 IPI00019912 Peroxisomal multifunctional enzyme type 2

A search for candidate proteins involved in metabolic pathways of arsenic toxicity response yielded a total of 33 proteins (11 increased abundance and 22 decreased abundance) associated with 18 metabolic process terms were identified

Table 5: Proteins in metabolic processes with decreased abundance to arsenic trioxide