Model 1 Model 2 Model 3a Model 3b Model 5 Model 6 reduced Model 5 # of SV 8 1 8 8 36 6 10 log L 202 -5975 -5996 -5981 -5732 -4976 -5704 # params 2746 3 13 13 41 11 15 AIC 5088 11957 12018 11988 11546 9975 11438 BIC 10973 11963 12046 12015 11634 9998 11470 # of SV=Number of splicing variants; log L=log likelihood; # of params=Number of parameters; AIC=Akaike information criterion; BIC=Bayesian information criterion. Model 1=Mclust model; Model 2=One splice variant; Model 3=Known splice variants; Model 5=Known and high mixture proportions splice variants; Model 6=Manually selected splice variants the .a and .b define normal model or the extended model respectively

Table 5: FBN1 Model results.