Rank Upregulated in Feature Description Score Feature P Fold Change SF Mean SF Std Rest Mean Rest Std 1 Rest P33241   lymphocyte-specific protein 1 -4.143 0.002 1.389 1.274 0.089 1.770 0.385 2 SF P04839 cytochrome b-245, beta polypeptide (chronic granulomatous disease) 3.983 0.020 1.358 0.630 0.056 0.464 0.108 3 Rest O76043 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -3.439 0.002 1.549 1.045 0.157 1.619 0.510 4 Rest P05106 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -3.399 0.008 1.284 1.702 0.172 2.185 0.393 5 SF Q13371 phosducin-like 3.367 0.052 1.323 0.334 0.015 0.252 0.080 6 SF Q13158 Fas (TNFRSF6)-associated via death domain 3.328 0.018 1.486 1.296 0.236 0.872 0.166 7 Rest P11279 lysosomal-associated membrane protein 1 -3.293 0.026 1.497 1.036 0.163 1.551 0.463 8 Rest P70281 synaptonemal complex protein 3 -3.232 0.040 1.288 1.342 0.115 1.729 0.364 9 Rest O43561 linker for activation of T cells -3.217 0.036 1.348 1.268 0.165 1.709 0.379 10 SF Q92886 neurogenin 3 3.140 0.032 1.684 0.276 0.063 0.164 0.059

Table 1: Candidate gender-independent SF-markers for Stable Function in kidney transplant patients. Microarray analysis using protein Ab arrays (Clontech-500) with pooled serum samples from kidney transplantation patients and controls was performed, as described in Material & Methods. Candidate SF-markers were identified in SF vs. Rest comparison (4-classes: NK, SF, AR, and CGI) using Comparative Marker Selection (Gene Pattern). Final selection was made using rank, score, feature P, and fold change.