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Figure 3: Pie charts obtained from GO analysis performed. The SILAC data used for the GO analyses were obtained by treating HepG2 cells with the respective compounds at 10 μM drug concentration for 48 hrs at 37°C. The numbers on each sector of a pie chart represent the number of proteins that changed significantly in the biological process. The colours of the sectors of the pie charts represent specific biological processes to which the protein changes have been allocated by the GO analyses (see key at the bottom of the figure). Note that not all proteins that changed could be allocated to a biological process due to lack of functional and structural information about these proteins in the databases used for GO analyses. |