Models Dependent variable: CD31+/annexin V+ EMPs to CD62E+ EMPs ratio AUC (95% CI) ΔAUC IDI ( ± SE) Relative IDI (%) Model 1 (based model: T2DM) 0.626 - - - Model 1 + OPG 0.681 - - - Model 1 + OPG vs Model 1 - 0.055; P<0.05 0.06 ± 0.010 10.2% Model 1 (based model: T2DM) 0.626 - - - Model 1 + hs-CRP 0.661 - - - Model 1 + hs-CRP vs Model 1 - 0.035; P=0.024 0.03 ± 0.012 5.1% Model 1 (based model: T2DM) 0.626 - - - Model 1 + OPG + hs-CRP 0.683 - - - Model 1 + OPG + hs-CRP vs Model 1 - 0.057; P<0.05 0.06 ± 0.009 11.1% Model 1 (based model: T2DM) 0.626 - - - Model 1 + adiponectin 0.655 - - - Model 1 + adiponectin vs Model 1 - 0.045; P=0.043 0.02 ± 0.010 4.6% Model 1 (based model: T2DM) 0.626 - - - Model 1 + adiponectin + OPG 0.664 - - - Model 1 + adiponectin + OPG vs Model 1 - 0.038; P<0.05 0.03 ± 0.008 7.9% Model 1 (based model: T2DM) 0.626 - - - Model 1 + hs-CRP + OPG + adiponectin 0.690 - - - Model 1 + hs-CRP + OPG + adiponectin vs Model 1 - 0.064; P<0.001 0.02 ± 0.015 12.6% Note: Relative IDI – calculated as the ratio of IDI over the discrimination slope of the model without T2DM. Abbreviations: AUC: Area Under Curve; SE: Standard Error; T2DM: Type Two Diabetes Mellitus; OPG: Osteoprotegerin; hs-CRP: High Sensitive C-Reactive Protein

Table 2: C-statistics for Models with T2DM, hs-CRP, OPG, and adiponectin as Continuous Variables.