Figure 2: Five sub-networks were highlighted with thick circles. Eleven small circles identified proteins that also served as hubs for groups of proteins. Proteins in red were the over-represented, while proteins in green were under-represented. Solid grey lines and dotted grey lines indicated direct and indirect interactions, respectively. Arrow-headed lines and simple lines without arrows indicated ‘acts on’ and ‘binding only’, respectively. Solid orange lines and dotted orange lines indicated highlighted direct and indirect interactions, respectively. Lines connecting the proteins indicated known interrelationships from the IPA database.