Figure 5: Canonical pathway and gene network analysis of the 18 identifiers that were expressed in the lungs of PQ-free rats. The 18 identifiers were analyzed using IPA and the identifiers were grouped to 11 canonical biological process pathways. The EGF signaling, PDGF signaling, NF-κB activation by viruses, ceramide signaling, regulation of IL-2 expression in activated and anergic T lymphocytes, and PTEN signaling were found to be the dominant canonical pathways represented by the identifiers. p-Value <0.05 indicated that a maximum False Discovery Rate of 5% was accepted in the functional analysis of IPA. A representative protein network of the dominant canonical pathways was then generated. The networks was obtained by merging the 2 highest scored networks into one overall network; cell signaling, cardiovascular system development (score 19), cell death (score 13). CSRNP3 and KCNH8 were not eligible to mapping. POU3F3 and EMCN were not involved in the highest scored networks. Solid grey lines and dotted grey lines indicated direct and indirect interactions, respectively. Arrow-headed lines and simple lines without arrows indicated ‘acts on’ and ‘binding only’, respectively. Solid orange lines and dotted orange lines indicated highlighted direct and indirect interactions, respectively.