| Protein name (gene symbol*) |
A† |
B† |
C† |
Biological function |
| p53 signaling pathway |
Tumor suppressor p53- binding
protein 1 (TP53BP1) |
14 |
160 (29) |
P70399 |
Checkpoint signal during mitosis |
B-cell lymphoma/leukemia 11B
(BCL11B) |
18 |
194 (29) |
Q99PV8 |
Tumor-suppressor protein involved in T-cell lymphomas, BCL-11B (Radiation-induced tumor suppressor gene 1 protein) |
Diphthamide biosynthesis protein
1 (DPH1) |
14 |
142 (29) |
Q5NCQ5 |
Tumor suppressor in lung and breast cancers |
Hypermethylated in cancer 1
protein (HIC1) |
15 |
160 (29) |
Q9R1Y5 |
Tumor suppressor (Development of head, face, limbs and ventral body wall) |
Chromosome transmission
fidelity protein 8 homolog
(CHTF8) |
18 |
158 (29) |
B2RYL1 |
Potential tumor suppressor |
| MAPK signaling pathway or related proteins |
| Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) |
14 |
136 (30) |
Q62925 |
Activation of JNKK activity up |
| Neurofibromin 1 (NF1) |
14 |
165 (30) |
P97526 |
MAPKKK cascade |
RAF proto-oncogene serine
/threonine-protein kinase (RAF1) |
13 |
145 (30) |
P11345 |
MAPKKK cascade |
Suppression of tumorigenicity
protein 18 (ST18) |
13 |
145 (30) |
Q9QX27 |
Negative regulation of transcription from RNA polymerase II promoter |
| Apoptosis |
Cysteine/serine-rich nuclear
protein 3 (CSRNP3) |
12 |
141 (30) |
P59055 |
Apoptosis |
| Pericentrin (PCNT) |
12 |
144 (30) |
P48725 |
Apoptosis |
Tripartite motif- containing
protein 35 (TRIM35) |
12 |
134 (30) |
Q5RKG6 |
Apoptosis |
| POU domain, class 3 (POU3F3) |
13 |
150 (30) |
Q63262 |
Negative regulation of apoptosis |
| Potassium voltage-gated channel subfamily H member 8 (KCNH8) |
12 |
141 (30) |
Q9QWS8 |
Negative regulation of apoptosis |
| Angiogenesis inhibition |
Brain-specific angiogenesis
inhibitor 2 (BAI2) |
14 |
166 (30) |
Q8CGM1 |
Angiogenesis inhibition |
| Endomucin (EMCN) |
12 |
137 (30) |
Q6AY82 |
Angiogenesis |
| B cell receptor |
Breast cancer anti-estrogen
resistance protein 1 (BCAR1) |
13 |
139 (30) |
Q63767 |
B cell receptor signaling pathway |
DNA-dependent protein kinase
catalytic subunit (PRKDC) |
15 |
150 (29) |
P97313 |
B cell lineage commitment
(serine/threonine-protein kinase) |
*Protein IDs uploaded into IPA were converted to the corresponding Entrez Gene symbols for display in Pathways and Networks. Ingenuity's knowledge base contained
published findings for both genes and proteins. However, for display purposes, only gene names were used (even when protein IDs were uploaded)