| Protein (gene symbol*) |
A† |
B† |
C† |
Biological function |
| c-Jun N-terminal kinase (JNK) pathway |
Dual specificity protein phosphatase 10
(DUSP10) |
15 |
143 (30) |
Q9ESS0 |
Negative regulation of JNK cascade |
C-jun-amino-terminal kinase- interacting
protein 2 (MAPK8IP2) |
18 |
296 (30) |
Q9ERE9 |
The JNK-interacting protein (JIP) |
| Extracellular calcium-sensing receptor (CASR) |
13 |
145 (30) |
P48442 |
JNK cascade |
| Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) |
14 |
136 (30) |
Q62925 |
Activation of JNKK activity |
| Immune response |
| Macrophage receptor (MARCO) |
14 |
255 (33) |
Q60754 |
Innate immune response |
| NLR family member X1 (NLRX1) |
13 |
251 (33) |
Q5FVQ8 |
Innate immune response |
| Fas apoptotic inhibitory molecule 3 (FAIM3) |
12 |
146 (32) |
Q5M871 |
Immunity |
| Protein THEMIS2 (C1orf38) |
15 |
141 (30) |
Q91YX0 |
Macrophage inflammatory response |
Complement decay-accelerating factor
transmembrane isoform (Cd55/Daf2) |
19 |
141 (33) |
Q61476 |
Complement pathway/Innate Immunity |
B-cell lymphoma 3-encoded protein homolog
(BCL3) |
15 |
258 (30) |
Q9Z2F6 |
T-helper 1 type immune response |
| Thioredoxin reductase 3 (TXNRD3) |
17 |
384 (30) |
Q99MD6 |
Glutaredoxin |
| E3 ubiquitin-protein ligase RNF125 (RNF125) |
14 |
252 (32) |
Q9D9R0 |
Immune response |
| Apoptosis |
Apoptosis-inducing factor, mitochondria -
associated 1 (AIFM1) |
14 |
143 (30) |
Q9JM53 |
Apoptosis |
Phosphofurin acidic cluster sorting protein 2
(PACS2) |
12 |
251 (32) |
Q3V3Q7 |
Apoptosis |
Dual specificity tyrosine- phosphorylation-
regulated kinase 2 (DYRK2) |
11 |
258 (30) |
Q5U4C9 |
Apoptosis |
Homeodomain-interacting protein kinase 2
(HIPK2) |
12 |
145 (30) |
Q9QZR5 |
Apoptosis |
| Angiogenesis |
| Roundabout homolog 4 (ROBO4) |
13 |
249 (33) |
Q80W87 |
Angiogenesis |
| ETS domain-containing protein (ELK3) |
14 |
145 (33) |
P41971 |
Angiogenesis |
| Collagen alpha-2 (IV) chain (COL4A2) |
12 |
140 (30) |
P08122 |
Angiogenesis |
| Nitric oxide synthase 3 (NOS3) |
12 |
140 (30) |
P70313 |
Lung development/ Cardiovascular-cancer-respiratory pathway |
| Neurotransmitters |
| Glutamate receptor, metabotropic 5(GRM5) |
13 |
252 (30) |
P31424 |
Neurotransmitters |
| Glutamate receptor, metabotropic 1(GRM1) |
16 |
143 (29) |
P97772 |
Neurotransmitters |
| Glutamate receptor, ionotropic (GRIA1) |
12 |
141 (33) |
P19490 |
Neurotransmitters |
| Activation of TP53/p53 |
| CDKN2A-interacting protein (CDKN2AIP) |
8 |
185 (32) |
Q8BI72 |
Activation of TP53/p53 |
| Chromatin modification |
| BCL-6 corepressor (BCOR) |
13 |
253 (32) |
Q8CGN4 |
Negative regulation of gene-specific transcription from RNA polymerase II promoter |
| Clathrin-mediated endocytosis |
| AP2-associated protein kinase 1 (AAK1) |
17 |
274 (32) |
P0C1X8 |
Clathrin-mediated endocytosis |
*the same as Table 1 footnote.