Reference Organism Stress condition Enzyme/Regulation# Glycolysis PP pathway TCA cycle Prokaryote         [36] Escherichia coli Cisplatin -Fructose-bisphosphate aldolase class 2 ↓ -phosphoglycerate kinase ↓ -2-Oxoglutarate dehydrogenase E1 component ↓   -Citrate synthase ↓ -Aconitate hydratase 1 and 2 ↓ [37] Escherichia coli Chlortetracycline -6-Phosphofructokinase isozyme 1↓ -2,3-Bisphosphoglycerate-dependent phosphoglycerate mutase↓ -Fructose-bisphosphate aldolase class 1↓ -Glyceraldehyde-3-phosphate dehydrogenase A↓ -Pyruvate kinase↓ -6-Phosphofructokinase isozyme 2↓ -Fructose-bisphosphate aldolase class 2↓ -Phosphoglycerate kinase↓ -Enolase↓ - Phosphoglucomutase↓ -Fumarate reductase flavoprotein subunit ↓ -Pyruvate dehydrogenase E1 component ↓ -Succinyl-CoA ligase [ADP-forming] subunit alpha ↓ -Aconitate hydratase 2 ↓ -Citrate synthase ↓ -Isocitrate dehydrogenase ↓ -Fumarate reductase iron-sulfur subunit ↓ -Succinate dehydrogenase iron-sulfur subunit ↓ -Fumarate hydratase class I ↓ -Malate dehydrogenase ↓ [39] Acinetobacterbaumannii (resistant strain RS307 vs ATCC 19606) Carbapenem     -Dihydrolipoamide dehydrogenase ↑ -Malate dehydrogenase ↑ -2-Oxoglutarate dehydrogenase complex ↑ [40] Escherichia coli Ultraviolet A -Enolase ↓ -Fructose-bisphosphate aldolase class 2 ↓ -Pyruvate kinase II ↓ -Transketolase 1 ↓ -Transketolase 2 ↓ -2-Oxoglutarate dehydrogenase E1 component ↓ -Pyruvate dehydrogenase E1 component ↓ -Aconitate hydratase 2 ↓ -Succinate dehydrogenase flavoprotein subunit ↓ -Dihydrolipoyl dehydrogenase ↓ -Acetyl-coenzyme A synthetase -Citrate synthase -Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex ↓ -Succinyl-CoA synthetase beta chain ↓ -Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex ↓ [43] Deinococcusradiodurans R1 6 kGy Irradiation     -Citrate synthase ↓ -Aconitate hydratase ↓ [45] Lactobacillus brevis NCL912 Acid stress -Glyceraldehyde-3-phosphate dehydrogenase ↑     [46] Streptococcus sobrinus Acid stress -Fructose-1,6-biphosphate adolase ↑ -6-Phosphofructokinase ↑ -Pyruvate kinase ↑ -Phosphoglycerate kinase ↑ -Glycerehyde-3-phosphate dehydrogenase ↑ - L-Ribulose 5-phosphate 4-epimerase ↑ -Aconitate hydratase aconitase ↑ -Citrate synthase ↓ [48] Acetobacterpasteurianus Acid stress (acetic acid) -Glyceraldehyde-3-phosphate dehydrogenase ↑   -2-Oxoglutarate dehydrogenase E2 component ↑ -Aconitate hydratase ↑ [49] Listeria monocytogenes Low temperature -Hypothetical protein lmo2457 similar to triosephosphate isomerase↑ -Glyceraldehyde-3-phosphate dehydrogenase ↑ -Phosphoglycerate kinase ↑ -Hypothetical protein lmo0907 similar to phosphoglycerate mutase family protein↑ -Enolase↑   -Hypothetical protein lmo1052 similar topyruvate dehydrogenase complex, E1 component ↑ -Pyruvate dehydrogenase alpha subunit ↑ -Hypothetical protein lmo1053 similar to pyruvate dehydrogenase E1 component subunit beta ↑ [50] Thermus sp. GH5 Cold shock -Fructose-1,6-bisphosphate aldolase, class II ↓ -Transaldolase ↑ -Ribose-5-phosphate isomerase ↑   [51] Bifidobacteriumlongum Bile -Pyruvate kinase ↑ -Pphosphoglycerate kinase ↑ -Glyceraldehyde-3-phosphate dehydrogenase C ↑ -Phosphoglycerate mutase ↑ -6-Phosphogluconate dehydrogenase decarboxylatin II ↑ -Fructose 6-phosphate phosphoketolas ↑ -Transketolase ↑   [52] Staphylococcus aureus Fluid shear rates (50, 100, 500 and 1000 s-1 Glyceraldehyde 3-phosphate dehydrogenase ↓   -Malate dehydrogenase ↑ -Succinyl CoA synthetase ↓ [53] Staphylococcus warneri SG1 Butanol -Glyceraldehyde 3-phosphate dehydrogenase 2 ↑ -6-Phosphofructokinase ↑ -Phosphoglycerate mutase ↑ -Fructose-1,6-bisphosphate aldolase ↑ -Pyruvate kinase ↑ -Aldose 1-epimerase ↑ -Glyceraldehyde-3-phosphate dehydrogenase ↓ -Triosephosphate isomerase ↓ -Ribose-5-phosphate isomerase A ↑ -Phosphopentomutase ↑ -Putative transaldolase ↑ -Transketolase ↑ -Succinyl-CoA synthetase subunit alpha ↑ -Succinyl-CoA synthetase subunit beta ↑ -2-Oxoglutarate ferredoxin oxidoreductase ↑ [54] Pseudomonas putida P8 Benzoate   -Transaldolase ↑ -Isocitrate dehydrogenase ↑ -Succinyl-CoA synthetase ↑ -Aconitate hydratase AcnB ↑ [55] Pseudomonas fluorescens Reactive nitrogen species     -Isocitrate dehydrogenase ↓ -Malate dehydrogenase ↓ -Aconitase ↓ [57] Anabaena sp. PCC7120 Arsenic -Fructose bis phosphate aldolase II ↓ -Phosphoglycerate kinase ↓ -Fructose 1,6 bisphosphatase ↓ -Transketolase ↓     Eukaryote         [60] Aspergillusfumigatus Hypoxia -Glyceraldehyde 3-phosphate-dehydrogenase ↑ -Phosphoglycerate kinase↑ -Enolase/allergen Asp F 22 ↑ -Fructose-bisphosphate aldolase class II ↑ -6-Phosphogluconate- dehydrogenase ↑ -Transaldolase ↑ -Dihydrolipoamidesuccinyltransferase ↑ -Aconitate hydratase ↑ -Succinyl-CoA synthetase ↑ -Succinate dehydrogenase subunit Sdh1 ↓ -Pyruvate- dehydrogenase complex component Pdx1 [61] Pichia pastoris Hypoxia -6-Phosphofructokinase gamma-subunit ↑ -Glyceraldehyde-3-phosphate dehydrogenase ↑ -Pyruvate kinase ↑ -Phosphoglucoseisomeras ↑ -Enolase ↑ -Fructose 1,6-bisphosphate aldolase ↑ -Phosphoglycerate mutase ↑   -Aconitase ↓ -Fumarase ↓ -Mitochondrial malate dehydrogenase ↓ [64] Debaryomyceshansenii NaCl -Enolase↓ -Phosphoglycerate mutase ↓ -Aldolase ↑ -Triosephosphate isomerase ↑   -Pyruvate dehydrogenase b-subunit ↓ [65] Boletus edulis NaCl -glyceraldehyde-3-phosphate dehydrogenase ↑     [66] Saccharomyces cerevisiae Vacuum fermentation -Glucokinase ↑ -Glucose-6-phosphate isomeras ↑ -Fructose-bisphosphate aldolase ↑ -Triosephosphate isomerase ↑ -Glyceraldehyde-3-phosphate dehydrogenase ↑ -Phosphoglycerate kinase ↑ -Enolase 2 ↑ -Enolase 1 ↑ -Glucose-6-phosphate dehydrogenase ↑ -Transketolase ↑ -Fumarate reductase ↑ [67] Fusariumoxysporum Crocidolite -Glyceraldehyde 3-phosphate dehydrogenase ↓ -6-Phosphogluconate dehydrogenase ↑   [69] Kluyveromyceslactis H2O2 WT: -3-Phosphoglycerate kinase ↑ -Pyruvate kinase ↓ -3-Phosphoglycerate kinase ↓ -Fructose-1,6-bisphosphate aldolase ↓ -Triosephosphate isomerase ↓ Δglr1: -Pyruvate kinase ↑ -Hexokinase isoenzyme 2 ↑ -Enolase ↑ -Glyceraldehyde-3-phosphate dehydrogenase 2 ↓ Δglr1: -6-Phosphogluconate dehydrogenase ↑ Δglr1: -Aconitase ↓ -Fumarase ↑ -Citrate synthase ↑ -Malate dehydrogenase ↑ [70] Alternariabrassicicola Phytoalexinbrassinin 0.5 mMbrassinin: -Triosephosphate isomerase ↑ -Pyruvate kinase ↑ -Glucose-6-phosphate isomerase ↑ -Similar to glucose-6-phosphate 1-dehydrogenase ↑ 0.5 mMbrassinin: -Transaldolase 1 ↑ -Putative 6-phospho- gluconolactonase ↑ 0.1 mMbrassinin: -Aconitate hydratase ↑ -Malate dehydrogenase ↑ -ATP citrate synthase ↑ [71] Alternariabrassicicola Phytoalexincamalexin (0.1 mM) -Putative glucokinase ↓ -Hexokinase ↓ -2,3-Bisphosphoglycerate-independent phosphoglycerate mutase ↓ -Pyruvate kinase ↓ -Phosphoglycerate kinase ↓ -Putative 6-phospho-gluconolactonase ↑ -6-Phosphogluconate dehydrogenase 1 ↑ -Phosphoglucomutase ↓ -Aconitate hydratase ↑ -ATP-citrate synthase ↓ -Putative aconitate hydratase ↓ -Putative isocitrate dehydrogenase subunit 2 ↓ [73] Candida glabrata Different pH pH 7.4/8.0 vs pH 4.0 -Glyceraldehyde-3-phosphate dehydrogenase ↓ -Pyruvate kinase ↓ -Fructose-bisphosphate aldolase ↓ -Glucose-6-phosphateisomerase ↓ -6-Phosphofructokinase, alpha subunit ↑ -6-Phosphofructokinase, betasubunit ↑ -Transketolase ↓ -Transaldolase ↑ -Aconitate hydratase ↓ -Malate dehydrogenase ↓ -Succinate-CoA ligase beta subunit ↓

Table 1: An overview of the proteomic analysis of differentially expressed enzymes from central carbon metabolic pathways that change under different stress conditions. # Up-regulation of enzymes are indicated by ↑ and down-regulation of enzymes are indicated by ↓.