Figure 4: Average binding cooperativiy of DNMT1 in CLL, normal Lymphocytes and in normal Granulocytes. The Y-axis represents the average binding cooperativity (n) of DNMT1 in CLL, normal granulocytes, and normal lymphocytes. The average value was calculated from the binding cooperativity of the eight tumor suppressor genes shown in Figure 3. Percent methylation of select genes in normal and CLL cells.