Profiling Methods Results Reference Biomarkers Antibody microarray Profiled MMPs/TIMPs signature in gastric garcinoma [6] Tissue microarray Identified novel prognostically significant tumor [29] Novel high-density custom protein microarrays (NAPPA) Detected 119 antigens to autoantibodies in breast cancer [30] ProtoArray Human Protein Microarrays v4.0 & tissue microarray Identified galectin-8, TARP and TRAP1 for biomarkers in prostate cancer [31] Protein microarray Profiled biomarkers in bladder cancer [32] Protein microarray Analysis of antibody responses in non-small cell lung cancer patients and healthy donors [33] ProtoArrays Discovered 15 potential tumour-associated antigens in ovarian  cancer [34] SELDI-TOF-MS protein microarrays Identified serum biomarkers for lung cancer [36] SELDI-TOF-MS protein microarrays Identified eIF2B-delta as the potential serum biomarkers for renal cell carcinoma [37] SELDI-TOF-MS protein microarrays & CT scan Distinguishes renal cell carcinoma from benign renal [38] SELDI-TOF MS based ProteinChip arrays profiling for diagnostic and prognostic bladder cancer biomarkers [39] Enzyme substrates Protein microarrays Found 11 known APC substrates polyubiquitinated. [44] Protein microarray Profiled ubiquitylation, SUMOylation and NEDDylation [45] Yeast Proteome Microarray Identified and validated the acetylation sites of Pck1p [46] Peptide microarray platform casein kinase I to phosphorylate a subset of the novel motifs [50] Small molecular Protein microarray Uncovered that triterpenoids associate with Arp3 [52] Protoarray Analysis of keratan sulfate, chondroitin sulfate A, and hyaluronic acid molecular interactions [53] Protein-protein interaction ImaGenes UniPex colony microarrays Identified a total of 112 novel NEMO interactors [54] ProtoArray Human Protein Microarray Identified GSK3 proteins as possible RKIP binding proteins [55] Antibody specificity Protein microarray Develop a high-affinity synbody that specifically binds AKT1 [62]

Table 1: Overview of protein microarray applications.