Transcriptomic analysis of kidney cortex from 24 wk old db/db diabetic mice and db/+ control mice for genes involved in ceramide metabolism identified altered expression of genes in ceramide synthesis and downstream sphingosine-1-phosphate signaling. Ingenuity® Pathway Analysis was used to visualize changes in both the canonical ceramide biosynthesis pathway and the sphingosine-1-phosphate signaling pathway. Green = significantly downregulated, pink = significantly upregulated, gray = unchanged.
