Figure 1: Domain structure, interacting partners, and downstream functions of DBC1. Boundaries for the nuclear localization signal (NLS, yellow), leucine zipper (LZ, brown), EF hand (orange), and coiled coil (blue) regions are indicated. Dotted lines represent predicted domains for RNA binding (red) and Nudix hydrolase (green) regions. Numbers refer to amino acid positions. The domain-dependent interactions and their biological effect are represented, pointing toDBC1 functions as a transcriptional co-factor via its activation or inhibition of chromatin remodeling enzymes and transcription factors. The phosphorylation at T454 residue (pink) in response to DNA damage is indicated.