Figure 6: Identification of protein networks: To identify networks and upstream proteins, we routinely employed the Ingenuity Pathways Analysis (IPA) system. We analyzed these networks using either the interaction protein profiles (Table 1), or regulated protein profiles independently (Table 3). The results of these analyses are demonstrated in Table 4. We found that both pathway lists included the MYC pathway as an upstream protein. We conducted a confirmation study and successfully confirmed MYC to be an upstream regulator of NPM1 in Ewing’s sarcoma (data not shown).