T2D Vs Controls PC Vs. Controls PT Vs. Controls PN Vs. Controls # peptides 92 (p < 0.05) 244 (p <0.005) 258 (p <0.05) 233 (p<0.0005) Accuracy 87.88 % 93.10 % 96.15 % 95.24 % Specificity 93.75 % 93.8 % 100 % 100 % Sensitivity 82.4 % 92.3 % 90 % 80 %

Table 2: Classification performance for predicting each disease with peptides from disease component. Table showing classification accuracy, specificity and sensitivity for each pancreas disease versus common controls. T2D = type II diabetes, PC = pancreatic cancer, PT = pancreatitis, PN = panIN.