Combo ID Amino acid combination Chronic Occult 2-sided p-value
8 W3+H9+N13+P20+R41+V43+V44+S50+
R51+T54+W58+L66+L73+S75+W79+L80+
V84+S85+F88+I91+T118+S119+F178+V207+
K212+L217+S223+I224+I233+L235+S246+V253+
Q262+E263+V278+I290+S317+P325+Y327+L331
32.42% 53.57% 0.0359
11 W3+G4+E8+H9+P20+L29+N36+T38+
R41+V44+S50+R51+T54+H55+W58+P59+
L66+L80+S85+F88+T118+S119+Q125+V142+
L144+Y148+K168+F178+I233+S246+V253+S256+
E263+R274+V278+C287+P325+A329+L331+N337
26.06% 53.57% 0.0037
11 W3+G4+E8+H9Y+P20+L29+N36+T38+
R41+V44+S50+R51+ T54+H55+W58+P59+
L66+L80+S85+F88+T118+S119+Q125+V142+
L144+Y148+K168+F178+I233+S246+V253+S256+
E263+R274+ V278I+C287+P325+A329+L331+N337
17.27% 0 0.0125
11 W3+G4+E8+H9+P20+L29+N36+T38+
R41+V44+S50+R51+T54+H55+W58+P59+
L66+L80+S85+F88+T118+S119+Q125+V142+
L144+Y148+K168+F178+I233+S246+V253+S256+
E263+R274+V278+C287+P325+A329+L331+N337H
15.45% 0 0.0209
12 D2+W3+G4+T7+E11+R15+P20+F28+
L29+K32+N36+T38+R41+S50+R51+H55+
W58+L66+L72+L73+W79+L80+V84+S85+
P109+S117+S119+N121+Y124+Q125+M129+S135+
S137+V142+L144+S159+I162+I169+V173+L180+
M204+K212+V214+L217+T225+L229+I233+F249+
V253+K270+Y305+P325+A329
49.09% 25% 0.0172
17 W3+T7+E11+R15+P20+F28+N36+T38+
R41+S50+R51+H55+W58+P59+L66+L73+
L80+S85+V103+G104+S119+Q125+H126+S135+
S137+N139+V142+L144+Y148+L164+L199+K212+
L217+S223+I224+I233+N238+K241+V253+Q262+
E263+L267+K270+C272+L311+A313+T322+P325+
Y327+A329
26.97% 46.43% 0.0471
18 W3+G4+E11+P20+L29+K32+N33+T38+
V44+S50+R51+T54+W58+L66+L72+L73+
N76+F88+V103+G104+P109+S117+N121+Y124+
Q125+M129+D131+L145+Y148+R153+I162+K168+
V173+F178+L180+M204+K212+V214+L217+E218+
T225+I233+K241+F249+S256+T322+L331+A342
54.24% 32.14% 0.0298
19 W3+G4+E8+H9Y+E11+R15+P20+L29+
K32+T38+R41+S50+R51+T54+H55+P59+
L66+L72+L73+W79+L80+V84+S85+F88+
T118+S119+Y124+Q125+H126+N139+V142+Y148+
I162+I169+V173+F178+K212+Q215+L217+I233+S246+
F249+V253+E263+K270+R274+V278I+A313+T322+
P325+A329+L331
15.45% 0 0.0209
22 D2+W3+G4+H9Y+P20+F28+L29+K32+
N36+T38+R41+V43+V44+S50+R51+T54+
H55+W58+P59+L66+L72+T118+S119+Q125+
Y148+S159+K168+I169+V173+V207+L217+T225+
I233+F249+S256+R274+V278I+C287+Y305+T322+
L331+N337
17.88% 0 0.0074
22 D2+W3+G4+H9+P20+F28+L29+K32+
N36+T38+R41+V43+V44+S50+R51+T54+
H55+W58+P59+L66+L72+T118+S119+Q125+
Y148+S159+K168+I169+V173+V207+L217+T225+
I233+F249+S256+R274+V278+C287+Y305+T322+
L331+N337H
18.18% 0 0.0072
26 D2+W3+G4+T7+H9+N13+P20+F28+
L29+K32+N36+T38+R41+V44+S50+R51+
S53+W58+P59+L66+L73+L80+S85+F88+
I91+S117+N121+I122+Q125+S135+S137+N139+
Y141+V142+L144+S159+I162+L180+M204+K212+
V214+L217+S223+I224+I233+L235+N238+S246+
F249+V253+Q262+E263+C272+V278+I290+Y305+
A313+S317+L331
25.45% 53.57% 0.0033
31 W3+H9+N13+P20+F28+L29+K32+R41+
S50+R51+G52+T54+H55+W58+P59+L66+
L72+L80+V84+S85+F88+I91+S117+N121+
Q125+S135+N139+V142+L144+Y148+F151+F166+
K168+L175+L180+M204+V214+L217+S219+T225+
I233+L235+S246+F249+V253+R274+V278+I290+
A313+S317+Q319+P325+L331+K333+N337
18.48% 35.71% 0.0446
32 D2+W3+G4+E8+P20+F28+K32+N36+
T38+V43+S50+R51+T54+H55+W58+P59+
L66+L72+L73+L80+S85+G104+V142+L144+
Y148+S159+I162+L164+I169+V173+F178+L199+
K212+T225+I233+N238+K241+F249+V253+S256+
L267Q+C287+Y305+L311+T322+P325+Y327+A329+C332
14.55% 0 0.0212
34 W3+G4+P20+F28+L29+N33+N36+T38+
R41+V43+V44+S50+R51+S53+P59+L66+
L73+S85+V103+G104+P109+T118+S119+N121+
Y124+M129+D131+Y148+K168+I169+V173+F178+
L180+M204+V207+K212+L217+I233+K241+N248+
F249+S256+T322+Y327+A342
60% 35.71% 0.0160
39 W3+G4+R15+P20+L29+K32+N36+T38+
R41+V43+S50+R51+T54+H55+W58+P59+
L66+L73+W79+L80+S85+F88+P109+S117+
S119+N121+Y124+Q125+D131+S135+V142+L144+
L145+Y148+I162+L164+K168+I169+V173+L180+
L199+V207+K212+V214+L217+T225+I233+F249+
S256+T322+Y327+A329+L331+A342
49.39% 28.57% 0.0474
41 W3+G4+T7+E11+P20+F28+N33+N36+
T38+R41+S50+R51+S53+W58+P59+L66+
L72+L73+W79+L80+P109+S117+T118+S119+
N121+Y124+M129+D131+S135+S137+L144+L145+
R153+I169+V173+L180+M204+K212+V214+L217+
T225+I233+N248+K270+L331+A342
55.76% 35.71% 0.0486
42 T7+H9+N13+P20+K32+T38+S50+R51+
S53+L66+L72+W79+L80+S85+F88+I91+
S117+N121+D131+S137+Y141+I162+K168+
F178+L180+L217+S223+I224+T225+I233+L235+
S246+F249+V253+Q262+E263+C272+V278+I290+
S317+L331+A342
31.21% 53.57% 0.0208
43 H9+N13+P20+F28+L29+K32+R41+V43+
S50+R51+T54+W58+P59+L66+L72+W79+
L80+V84+S85+F88+I91+S135+N139+V142+
L144+Y148+I169+F178+L180+V207+L217+
S223+I224+T225+I233+L235+S246+F249+
V253+Q262+E263+C272+V278+I290+S317+
T322+P325+L331
28.79% 50% 0.0304
44 W3+G4+E11+R15+P20+F28+L29+K32+
N36+T38+R41+V43+V44+S50+R51+T54+
H55+L66+L72+V84+S85+F88+V103+G104+
P109+T118+S119+N121+Y124+Q125+M129+S135+
V142+L144+L145+Y148+I162+L164+K168+I169+
V173+F178+L180+L199+M204+V207+V214+L217+
T225+I233+K241+F249+K270+L311+Y327+L331
48.48% 28.57% 0.0491
Table 5: Detailed interactions for H4 positions in genotype-C.