Amino acids genotype-C chronics genotype-C OBI genotype-D chronics genotype-D OBI L140+S143 1 1 0.975903614 0.916666667 L140+S143L 0 0 0.012048193 0 L140+S143P 0 0 0.012048193 0 L140F+S143T 0 0 0 0.041666667 L140+S143I 0 0 0 0.041666667

Table 16: Distribution comparison of amino acids at positions 140 and 143 in genotype-C and genotype-D.