Application Type of Assay Sample / Co-Factor Array Platform Reference
RNA-binding proteins Protein-RNA interaction Fluorescently labelled total or mRNA Yeast proteome array [67]
DNA-binding proteins Protein-DNA interactions Fluorescently labelled DNA oligonucleotides Human protein microarray [134]
Kinase substrate identification Protein phosphorylation Radioactive ATP Yeast protein microarray [28]
Protein kinase activity Enzyme kinetics Radioactive ATP Peptide microarray [77]
Protein-protein interaction quantification Protein-protein interactions Labelled peptides Protein domain microarray [84]
Posttranslational modification Protein sumoylation Antibodies Protein microarray [24]
Interactome analysis Protein-protein interaction Antibodies Human protein array [6]
Host-pathogen interactions Protein-protein interaction Antibodies Human protein microarray [27]
Biomarker discovery Protein-protein interactions Antibodies E. coli proteome chip [79]
Drug discovery Protein-small molecule interaction Labelled ligands Yeast proteome [88]
Table 1: Applications of protein arrays.