Study (Year) |
Proteomes Analyzed |
Biomarker(s) Identified |
Changes in Biomarker(s) |
Biomarker(s)
Function |
Li et al. [31] |
Receptive vs. non-receptive endometria |
Annexin A4 |
2.1 times higher in receptive compared to non-receptive endometria |
Apoptosis; mediates endometrial cells from pre-receptive to receptive state |
Dominguez et al. [30] |
i) Receptive vs. non-receptive endometria;
ii) refractory endometria |
Annexin A2 |
i) 1.9 times higher in receptive compared to non-receptive endometria;
ii) low levels in refractory endometria |
Cellular adhesion; implantation |
Dominguez et al. [30] |
i) Receptive vs. pre-receptive endometria |
Stathmin1 |
i) High levels in pre-receptive endometria;
ii) low levels in receptive endometria;
iii) dysregulated levels in refractory endometria |
High levels stimulate stromal proliferation for implantation; low levels destabilize microtubules for decidualization; dysregulated levels inhibit decidualization |
Scotchie et al. [25] |
Proliferative vs. secretory endometria |
Fibrinogen y chain |
Increased levels in proliferative endometria |
Vascularization |
Palmar et al. [37] |
Early secretory vs. mid-secretory endometria |
Alpha 1 trypsin |
Increased in early secretory endometria |
Protease inhibitor |