Subfamily NRPred-FS iNR-PhysChem NR-2L ACC MCC ACC MCC ACC MCC NR1 0.99 0.87 0.88 NR2 0.95 0.93 0.85 NR3 1.00 0.95 0.86 NR4 1.00 0.84 0.70 NR5 0.91 0.91 0.86 NR6 1.00 1.00 1.00 NR0 0.91 0.81 0.86 Overall 0.97 0.91 0.87

Table 5: Comparison of the prediction results among NRPred-FS, iNR-PhysChem and NR-2L in identifying the subfamilies of NRs by the LOOCV on the old dataset.