Network name Species Strain Release Reference Genome Source  iIN800 Saccharomyces cerevisiae  S288c  2008 Nookaew et al. [2] SGD1  iWV1314 Aspergillus oryzae  RIB40  2008 Vongsangnak et al. [3] DOGAN2  iHD666 Aspergillus nidulans  FGSC A4  2008 David et al. [4] AspGD3  iMA871 Aspergillus niger  ATCC1015  2008 Andersen et al. [5] AspGD3  iIB711 Streptomyces coelicolor  A3(2)  2005 Borodina et al. [6] S. coelicolor genome4

Metabolic networks were retrieved from BioMet Toolbox website (http://biomettoolbox.org/). The corresponding genome sequence was downloaded from sources listed in last column. 1http://www.yeastgenome.org/ 2http://www.bio.nite.go.jp/dogan/top 3http://www.aspgd.org/ 4http://www.sanger.ac.uk/resources/downloads/bacteria/streptomyces-coelicolor.html

Table 1: Metabolic networks used in our study.