SPACER SIZE ORGANISM CRISPR NO_SPACER POSITION IN ARRAY Spacer similarity within a strain AAAGAGGTATCTTTCAACTCAGGAAGTTCATTTGCAG 37 Methanothermococcus okinawensis H1 4_42, 9_17 CAATTTTCCGTCAGATTAAAATTTTGAAATCATTATATCC 40 Methanotorris igneus Kol 5 18_4, 19_4 TAGTCGTAACATCTTCTTATAGTTTTATCGTTAAATA 37 18_3, 19_3 TTTCACACTTGTTTATTATGAAATCCATACAAATCTT 37 18_2, 19_2 ATTGTAAATTGGTTCAAAGATTATGGCATTGATGT 35 18_1, 19_1 AAACAAGGATAGAAAATACTGCACTCGAAAACTCGAAAGTTCGAACACCTA 51 14_2, 7_5 TGAGTAGATATATAGTGGATTTAATAGGCGATGGTTGTTTGAATACCTC 49 14_1, 7_4 GTGGCTGCAGATCGTATATCTGATCATCTCAGAATAATGA 40 Methanosaeta concilii GP6 5_8, 7_2 GCTCTGGCCGCACCCCGGACAATGGCCAAGAAGATGGCGGT 41  5_7, 7_1 CGGCTCATACGGCATGGATGCCCTAACCAAGATGGT 36 5_5, 6_17 AGCTGATCAACGATTCTGCCAGCCAGGGCTTCAAAAAG 38  5_4, 6_16 AGAAGCCCCACAAGCAGAGCCACCGGGAAGAATGCA 36  3_3, 4_6 GTTCACTTTGTAATGCCACGGGCTGTACGCATTTC 35 3_2, 4_5 ATGGAAACGTCTTTGAACAAATGGCAAAGGAAGTTGCCAC 40  3_1, 4_4 TTAAAATAAACGATCCATTTGGTTGGGGTTCGAATAA 37 Methanocaldococcus vulcaniusM7  10_16, 20_1 AAGGGTTCCCCGTCAAAGTCGTTGGAGACAACAGC 35 10_15, 20_2 ACATAGAACAGATTAAAATAAGTGATTTAAAAAGGAAG 38 10_11,12,13,14 20_3 AGCTAAGCAACCGCAACAACAACAACAAAGCACACTTGC 39 Fervidicoccus fontiskam940 4_10,5_8 ACTACCTTTGGCAGGAGTTATACGAGAAGAAACTAA 36 4_11,5_7 AAAAACAATCGAAGAGGACATAGAAAACTTAAGAGAA 37 4_12,5_6 GGATCCCCAGCGTTGACATATACGAAACGAACTCGTC 37 4_13,5_5 CGAAGACAAAAGTAAGCAAGATGAAATAGCGGATTT 36 4_14,5_4 TTGGTAGGCGCAATTACGTTTATTAGCCAACTGAACGC 38 4_9,5_9 AACGAGGGTAGTGAATTCGAGGAGGGTATCATTATGATGCCCGAGAG 47 Vulcanisaeta distributa DSM 14429 8_10,9_2 CTCGAGCTGGCTTACTGGTGGTGGCGGTAGTGACTTCGGCACGAG 45 8_9,9_3 TTCTAATAATCACGAGTACGACGTCTTCGTCGTCAT 36 Pyrococcus yayanosii CH1 3_4, 4_4 TCGTTTTCTTCATTATTATCTATGTCATTACACCTAT 37 3_5, 4_5 CGGGGCGCGAGCCGGCGGGAAATCCGCCCCCGCGGGG 37 3_6, 4_6 CTGGATCTCTCTGAATTCTTCTGGATCACTAGTAACCT 38 3_7, 4_7` CCCGCCCACTTGTTGCTCATGTAGACCTTTCCTGAC 36 Haloarcula marismortui plasmid pNG400 1_1,3_40 TCGTTTTCTTCATTATTATCTATGTCATTACACCTAT 38 Haloquadratum walsbyi C23 2_6,3_12 Spacer similarity among the strains TTCTTCGACAGGCAGGGAGAGGAGAGGTACGCGCTGTACAAG 42 (A) Pyrobaculum arsenaticum DSM13514 & (B) Pyrobaculum oguniense TE7 A3_88 B4_2 ATTAGTATTTGGTCTAGCAGGTCTTTTATTTGTAGATATTCT 42 A3_89 B4_1 AAATATGTGAAGACGAAGCAATTGCAAGGGTAATATACACTAA 43 (A) Sulfolobus islandicus L D 8 5 & (B) Sulfolobus islandicus L S 2 15 A3_1 B2_1 TAGGACTATAAATGAAATTAAGAACACGA 29 (A) Sulfolobus islandicus Y N 15  51& (B) Sulfolobus islandicus REY15A A1_1 B8_3 CAAGGAGATTGAGGAAACCAAGAAAATAA 29 A1_2 B8_2 CAATTGCGTCAATGAGTTTATTTAAATCGTCAGCAATTAA 40 (A) Sulfolobus islandicus Y G 57 14& (B) Sulfolobus islandicus Y N 15  51 A1_1 B4_65 AAAATAACAAATTTCAAAGAAGGTAAAGTGAAAAGTGAC 39 A1_2 B4_64 Spacer similarity within chromosome and plasmid ATTACGGCGAATGGACGCTCGATATGACGTTTGACGAT 38 Natronomonas pharaonis DSM 2160 & Natronomonas pharaonis DSM 2160 plasmid PL23 5_2,1_1 GTTGCGGTCGACGATTCAGGCGACCAACTCGAAC 34 5_3,1_2 AAAGATACGCTCAGGCGTTGTCTCCCGCAACCCAT 35 5_4,1_3 AACGTCCCTGATTCAACGCGGATTGGGTCGGTTGCA 36 5_5,1_4 TGAAGGTAAAGATATCGTCGTCAATCATGAAAACC 35 5_6,1_5 TCGCTAGTCATCGGTCAGGCCCTCCGGGCTGGTGGT 36 5_7,1_6 CGTCGGCGTCTCGCTCGACGACCGTGCCCGTCGA 34 5_8,1_7

Table 3: Organisms with CRISPRs sharing same spacer sequences.