Organism Cas 1 Cas 2 Cas 3 Cas 4 Cas 5 Cas 6
Methanosarcina barkeri str fusaro 1     1   1
Methanosalsum zhilinae DSM 4017, 1 1 1   1  
Methanococcoides burtonii DSM 6242 2   2 1 1 1
Methanosaeta thermophila PT 2 1 1 2 2  
Methanosaeta concilii GP6 2 1 4 1 3  
Methanosaeta harundinacea 6Ac 1 1   1    
Methanospirillum hungatei JF-1 7     2 2  
Methanoculleus marisnigri JR1 1          
Methanocorpusculum labreanum Z 1     1    
Methanothermococcus okinawensis IH1 1 1   1   1
Methanococcus maripaludis X1 1 1 1 1 1  
Methanococcus maripaludis C5 1 1 1 1 1  
Methanococcus Vol.tae A3 2 2 2 2 2  
Methanococcus vannielii SB 2 2 1 1 1  
Methanococcus aeolicus Nankai-3 1 1 1 1 1  
Methanotorris igneus Kol 5 1 1   1    
Methanocaldococcus vulcanius M7 1 2 1 1 1  
Methanocaldococcus infernus ME 2 2 2 1 2 2
Methanocaldococcus fervens AG86 1 1 1 1 1  
Methanocaldococcus sp. FS406-22 1 1 1 1 1  
Methanobrevibacter ruminantium M1 2 2 1 1 1 1
Methanobacterium sp. SWAN-1 1 1 1 1 1 1
Methanocella sp. HZ254 1 1 1 1    
Acidilobus saccharovorans 345-15 1     2    
Aeropyrum pernix K1 1 1 2   1  
Desulfurococcus kamchatkensis 1221n 1 1   1 1  
Desulfurococcus mucosus DSM 2162 2   1 2 1  
Fervidicoccus fontis Kam940 1 1   1    
Hyperthermus butylicus DSM 5456 1 1 1 2    
Ignicoccus hospitalis KIN4 2 1 1 2    
Desulfurococcus fermentans DSM 16532         1  
Ignisphaera aggregans DSM 17230 1 1 1 2 1  
Metallosphaera cuprina Ar-4 1 1 1   1  
Metallosphaera sedula DSM 5348 1 1 3 1 1 1
Pyrobaculum aerophilum str. IM2 2 2 4 3 1  
Pyrobaculum arsenaticum DSM 13514 1 2 2 3   2
Pyrobaculum calidifontis JCM 11548 1 1 1 2    
Pyrobaculum islandicum DSM 4184       1   1
Pyrobaculum oguniense TE7 3 2 1 2   1
Pyrolobus fumarii 1A 1 1 1 2 2  
Staphylothermus hellenicus DSM 12710       1    
Staphylothermus marinus F1 1 1 1 2 1  
Sulfolobus acidocaldarius DSM 639 1 1   1   6
Sulfolobus solfataricus 98/2 2 2 1 3 1 1
Sulfolobus solfataricus P2 2 2 5 3 3 5
Sulfolobus tokodaii str. 7 3 2 4   1  
Thermofilum pendens Hrk 5 1 1 1 2 1  
Pyrobaculum neutrophilum- strain V24Sta 2 2 2 3 2  
Thermoproteus tenax Kra 1     2 2    
Thermosphaera aggregans DSM 11486 1 1 1 1    
Vulcanisaeta distributa DSM 14429 1 2   2 2 2
Vulcanisaeta moutnovskia 768-28 1 1 1 2   2
Acidianus hospitalis W1 2 2 1 2 1 2
Sulfolobus islandicus L.D.8.5 2 1 1 2   1
Sulfolobus islandicus L.S.2.15 1 2 1 2 1 1
Sulfolobus islandicus M.14.25 2 2 2 2 2 3
Sulfolobus islandicus HVE10/4 2 1 2 2 1 2
Sulfolobus islandicus M.16.27 2 2 2 2 2 3
Sulfolobus islandicus M.16.4 1 1 1 2 1 1
Sulfolobus islandicus REY15A 1 1 1 3 1 1
Sulfolobus islandicus Y.G.57.14 1 1 1 2 1 1
Sulfolobus islandicus Y.N.15.51 1 1 1 2 1 1
Pyrobaculum sp. 1860 3 2 1 3 1 2
Archaeoglobus veneficus SNP6       1    
Ferroglobus placidus DSM 10642 1 1   1    
Pyrococcus furiosus COM1 1          
Pyrococcus yayanosii CH1 2 1 3 3 2 2
Pyrococcus sp. NA2         1  
Thermococcus barophilus MP 1   1 1   2
Thermococcus gammatolerans EJ3     1 1 1 3
Thermococcus sibiricus MM 739 1          
Pyrococcus sp. ST04   2 1 2   3
Thermococcus sp. 4557 2 1 1   1  
Thermococcus sp. AM4 1 1 1 1 1 2
Thermococcus sp. CL1 3 3 1 1 2 2
Candidatus Korarchaeum cryptofilum OPF8 chromosome 1 1 1 1 1  
Haloarcula hispanica ATCC 33960  chromosomeII 1 1 1   1 1
Haloarcula marismortui ATCC 43049 plasmid pNG400 1 1 - 1 - -
Haloferax volcanii DS2 1 1 1 1 1 1
Halomicrobium mukohataei DSM 12286 1 1   1 1 1
Haloquadratum walsbyi C23 2 2 2 2 1 1
Halorhabdus utahensis DSM 12940 1 1 - 1 - 1
Halorubrum lacusprofundi ATCC 49239 plasmid pHLAC01 2 2 - 2 - 1
Table 4: CAS genes associated with the CRISPR found in the archaeal strains –Among 110 archaeal strains, the following holds CAS genes in their CRISPRs whereas in the remaining 27 strains CAS genes are absent but show the presence of unclassified and putative CAS genes.