Power of sonification pH aqueous phase Particle size (nm ) PDI Encapsulation efficiency  DL (%) 30 7.4 249.6 ± 9.79 0.088 ± 0.022 7.12 ± 1.44 4.22 ± 0.83 30 9 349.3 ± 21.82 0.176 ± 0.037 32.74 ± 0.512 19.13 ± 0.38 45 9 333.0 ± 45.80 0.136 ± 0.026 41.09 ± 8.00 25.29± 4.65 60 9 327.5 ±15.42 0.137 ± 0.017 52.82 ± 6.14 31.74 ± 3.63

Table 5: Effect of power of sonication and of pH of the aqueous phase on particle size, polydispersity (PDI), encapsulation efficiency and drug loading (DL) at the TDL 30 (% w/w), PVA = 0.5 (% w/v), PLGA = 1.3 (% w/v).