GROUPS p valuea
Parameter Score Group 1 Control Group 2a Paracetamol Group 3 ERD Treatment Group 4 NAC Treatment Group 5 NAC Control Group 6 ERD Control
n n n n n n  
Degenerationb None 0 0 0 0 0 0 <0.01
Mild 3 1 2 5 5 5
Moderate 2 4 3 0 0 0
Severe 0 0 0 0 0 0
Edemab None 0 0 0 4 3 5 <0.001
Mild 5 3 5 1 2 0
Moderate 0 2 0 0 0 0
Severe 0 0 0 0 0 0
Vascular Congestionc None 0 3 0 4 3 5 =0.006
Mild 3 2 5 0 2 0
Moderate 2 0 0 1 0 0
Severe 0 0 0 0 0 0
Total None 5 5 5 5 5 30
NAC: N-acetyl cysteine; ERD: erdosteine
aComparing of Group 2 vs. other groups; statistically significant difference in degeneration and edema, and vascular congestion effects (p<0.01)
bComparing of Group 3 vs. Group 4; no statistically significant difference in degeneration and edema effects (p>0.05)
cComparing of Group 3 vs. Group 4; statistically significant difference in vascular congestion effect (p<0.005)
Table 1: The results of histological examination of rat hippocampal tissues