Table 4

Nucleophile	Cisplatin	BNP3029
OH₂	27.7 23.8^b, 24.1^c,24.3±1.5^d	28.6
Guanine	21.1 23.4e	24.0
Adenine	30.3	34.5
SCH₃^-1	14.9	15.7
SHCH₃	27.8	29.3

aThermal corrections to the free energies were obtained from frequency calculations
at 25 ºC and 1 atm.
When comparing the calculated activation energy barriers with experimental data, the calculated energy barriers were corrected for liquid-phase concentrations of 1 mol/L by subtracting 1.9 kcal/mol from the calculated activation energy barriers.
^bSee reference 34.
^cSee reference 33.
^dSee reference 12.
^eSee reference 35.

Table 4: Activation free energiesa for the nucleophilic attack of water on cisplatin and BNP3029; or for the nucleophilic attack on monoaquated cisplatin or BNP3029 by guanine, adenine, thiolate and thiol. Bold numbers refer to the experimental activation free energies.