Figure 1: Contractile responses of cerebral arteries incubated in the absence (24 h) or presence of xestospongin C (XeC) or KN93. A, Maximum contractile responses (Emax) induced by K+, S6c and endothelin (ET-1) in mN shows here. B. Concentration-response curve for ETB receptor-mediated contraction induced by S6c calculated as a percentage of ET-1-induced contraction. *P<0.05, **P<0.01 and ***P<0.001 compared to 24 h. n = 6-8.