Figure 3:Endothelin receptors mRNA levels were evaluated by real time PCR. A, ETA receptor mRNA level did not changed after 24 h organ culture but IP3R inhibitor (XeC) decreased significantly ETA receptor mRNA level ** P < 0.01 compared to 24h, and B, ETB receptor mRNA levels increased significantly after organ culture compared to fresh ^^^ P < 0.001. XeC and KN93 decreased significantly ETB receptor mRNA levels compared to 24 h* P < 0.05, *** P < 0.001. n = 5.