Figure 6: Schematic illustration of the proposed interplay between organ culture, calcium, CaMKII and IP3R that leads to regulation of endothelin receptors. Organ culture induce increase in intracellular calcium and CaMKII expression while decreased the IP3R expression. Inhibition of DREAM by CaMKII and NFAT by XeC attenuated the effect of organ culture on endothelin receptors.