Score Cutpoint Sensitivity (%) Specificity (%) PPV (%) NPV (%) Model mRS < 2 0 100 24 36 100 1 99 38 40 99 2 94 56 47 96 3 87 73 58 93 4 70 83 63 87 5 37 95 74 78 Model mRS < 3 0 100 30 51 100 1 99 47 58 97 2 93 66 67 93 3 80 81 76 85 4 64 91 83 77 5 31 98 91 66 Model mRS > 4 1 98 37 40 98 2 94 43 41 95 3 92 55 46 94 4 86 69 55 91 5 78 76 59 89 6 68 87 69 86 7 59 92 76 83 8 49 96 84 81 9 41 98 89 79 10 31 99 94 77 11 20 100 94 74 12 11 100 100 72

Table 3: Specificity and sensitivity of the score cutpoints of the prognostic index in the development cohort. NPV and PPV – negative and positive predictive values.