Author/ Year Randomization – sequence generation Allocation Concealment Assessor Blinding Patients blinded Incomplete Outcome Data Selective Outcome Reporting Lonbro et. al., 2013, Radiother Oncol [12] Unclear Unclear Yes No No Yes Lonbro et. al., 2013 Acta Oncol [14] Unclear Unclear Yes No No Yes Rogers et al., 2013 [18] Yes Yes No No Yes Yes Samuel et al., 2013 [19] Unclear No No No No Yes

Tool used: the Cochrane Collaboration tool for assessing risk of bias [16], Reported as: No – high risk of bias; Yes – low risk of bias; unclear

Table 2: Risk of bias of included randomized controlled trials.