Day 1, 2 Day 3, 4 Day 5, 6, 7 Day 8, 9, 10 Day 11, 12, 13 Day 14-28 Washout Day 28-35 A 5 mg/day 5 mg bid 5 mg tid 5-5-10 mg 5-10-10 mg 10 mg tid Placebo B Placebo Placebo Placebo Placebo Placebo Placebo Placebo

Table 1: Dosing sequence for 4-AP during the trial.