Baseline HR (bpm) 70.3 ± 13.8 Peak exercise HR (bpm) 110 ± 21 Δ Exercise HR (bpm) 40.4 ± 16.6 Δ HR – 1 min (bpm) 10.1 ± 8.6 Δ HR – 2 min (bpm) 18.2 ± 10.1 Δ HR – 1/3 exercise (bpm) 18.5 ± 10.5 Peak VO2 (m/kg/min) 14.7 ± 4.5 VE/VCO2 slope (units) 35.6 ± 13.6 (32.3; 27.5-39.8) HR recovery – 1 min (bpm) 15.4 ± 15.8 HR recovery – 2 min (bpm) 24.9 ± 13.3 CL exercise duration (seconds) 679 ± 532 (526; 269-923)

Table 2: Hemodynamic and gas exchange parameters. HR: Heart Rate; CL: Constant Load. Δ Exercise HR: increase exercise HR during the RAMP exercise test; Δ HR: increase in heart rate at 1-minute (Δ HR – 1 min), 2-minutes (Δ HR – 2 min) and at 1/3 of exercise time (Δ HR – 1/3 exercise). Values in parentheses are median, Q1-Q3 for parameters not distributed normally.