Drug Weight Gain Risk of Diabetes Worsening Lipid Profile
Clozapine + + + + +
Olanzapine + + + + +
Risperidone + + D D
Quetiapine + + D D
Aripiprazole* +/–
Ziprasidone* +/–
+=increase; –=no effect; D=discrepant results.
*Newer drugs with limited long-term data [51].
Table 6: Metabolic Abnormalities with Atypical Antipsychotics.