Genotype Grade 3-4 toxicities Number of patients Regimen of chemotherapy Homozygous GG 1627A>G* Grade 3 neutropenia Grade 4 neutropenia 2 2 FAC, CMF 5-FU+CDDP, FOLFIRI Heterozygous GA 967G>A ** Grade 3 neutropenia 1 FOLFOX4 Heterozygous CT 1774C>T ** Grade 3 neutropenia 1 5-FU+Leucovorin Heterozygous IVS14+G>A Grade 4 neutropenia 1 5-FU+Leucovorin Heterozygous AT 1011A>T None 1 FAC Heterozygous GA 1236G>A Grade 4 neutropenia 1 FAC Heterozygous TC 1896T>C Grade 3-4 neutropenia 18 in 30 Various regimen Homozygous CC 1896T>C Grade 3 neutropenia 1 in 3 5-FU+Leucovorin * 1. Statistically significant difference in actual change of ANC and actual change of percentage of neutrophil after the first or second cycle of chemotherapy. 2. Amino acid was changed from isoleucine to valine but the group of amino acid was the same (aliphatic amino acid). ** Group of amino acid was changed

Table4: The correlation of genotype and phenotype in seven SNPs which found in exon.