Reference N Study design Statins Statin PK genes [20] 88 Prospective trial simvastatin CYP2D6 [38] 137 Case-control atorvastatin CYP3A4 CYP3A5 [26] 146 Prospective trial simvastatin ABCB1 CYP3A4 CYP3A5 [12] 28 Case-control atorvastatin ABCB1 SLCO1B1 CYP3A5 [22] 100 Case-control simvastatin fluvastatin pravastatin atorvastatin rosuvastatin CYP3A5 CYP2C9 CYP2D6   [21] 263 Case-control and longitudinal study atorvastatin simvastatin CYP2D6 CYP3A4 CYP3A5 CYP2C9 CYP2C8 [18] 16,839 Case-control simvastatin GWAS [23] 452 Prospective, randomized trial atorvastatin simvastatin pravastatin CYP2D6 CYP2C8 CYP2C9 CYP3A4 SLCO1B1 [33] 76 Case-control atorvastatin rosuvastatin SLCO1B1 [42] 46 Retrospective cohort atorvastatin pravastatin simvastatin lovastatin rosuvastatin fluvastatin SLCO1B1 [41] 98 Retrospective cohort atorvastatin ABCB1 [43] 793 Cross-sectional simvastatin atorvastatin rosuvastatin pravastatin lovastatin fluvastatin SLCO1B1 [30] 399 Case-control atorvastatin simvastatin cerivastatin pravastatin GWAS [32] 4,196 Observational cohort simvastatin atorvastatin pravastatin fluvastatin cerivastatin rosuvastatin SLCO1B1 [35] 109 Case-control simvastatin atorvastatin pravastatin rosuvastatin SLCO1B1 [45] 8782 Sub-study of clinical trial rosuvastatin SLCO1B1 [34] 488 Case-control simvastatin atorvastatin cerivastatin pravastatin rosuvastatin fluvastatin SLCO1B1 [27] 66 Case-control atorvastatin rosuvastatin simvastatin ABCB1 ABCG2 SLCO1B1

Table 2: List of reviewed studies meeting inclusion & exclusion criteria by publication year.