Polymorphism Allele variant Amino acide change Location Position Enzyme activity NCBI dbSNP rs CYP2C9*2 c. 430C>T R144C 10q23.33 Exon 3 decreased rs1799853 CYP2C9*3 c. 1075A>C I359L 10q23.33 Exon 7 decreased rs1057910 VKORC1 c. 173+1000C>T   16p11.2 Intron 1 decreased rs9934438 VKORC1 c. 173+1369G>C   16p11.2 Intron 2 decreased rs8050894 СYP4F2 c. 1297G>A V433M 19p13 Exon 2 decreased rs2108622 GGCX c. 1913+45G>C   2p11.2 Intron decreased rs11676382 CYP2D6*3 c. 622delA frameshift Arg208Glyfs 22q13.2 Exon 5 none rs35742686 CYP2D6*4 c. 353-1G>A splicing defect 22q13.2 Intron 3 none rs3892097 CYP1A2*1F c. -9-154C>A promoter 15q24.1 Intron incresed rs762551

Table 1: Characteristic of studied allele variants of the CYP2C9, VKORC1, CYP4F2, GGCX, CYP2D6 and CYP1A2*1F genes.