Polymorphisms Number of samples Hardy – Weinberg equilibrium Allele na Frequency Genotype nb Frequency CYP2C9*2 437 p=0.66 C T 856 18 0.98 0.02 СС СT TT 419 18 0 0.96 0.04 0.00 CYP2C9*3   444 p=0.54 A C 863 25 0.97 0.03 AA AC CC 419 25 0 0.94 0.06 0.00 VKORC1 1173 286 p=0.76 C T 162 410 0.28 0.72 CC CT TT 24 114 148 0.08 0.40 0.52 VKORC1 1542 259 p=0.65 G C 142 376 0.28 0.72 GG GC CC 18 106 135 0.07 0.41 0.52 CYP4F2 284 p=0.26 G A 396 172 0.70 0.31 GG GA AA 134 128 22 0.47 0.45 0.08 GGCX 266 p=0.57 C G 514 18 0.97 0.04 CC CG GG 248 18 0 0.93 0.07 0.00 CYP2D6*3 287 p=0.86 A del 568 6 0.99 0.01 AA A/del del/del 281 6 0 0.98 0.02 0.00 CYP2D6*4 343 p=0.15 G A 637 49 0.93 0.07 GG GA AA 294 49 0 0.86 0.14 0.00 CYP1A2*1F 257 p=0.63 A C 332 182 0.65 0.35 AA AC CC 109 114 34 0.42 0.44 0.13 а number of chromosomes; bnumber of alleles

Table 6: Allele frequency and genotype distribution in the Kazakh population