Allele Allele frequency Significant differences North Kazakhstan n=72 North-east Kazakhstan n=146 South Kazakhstann=70 CYP2C9*2 (C430T) С=0.94 Т=0.06 С=0.98 Т=0.02 С=0.97 Т=0.03 χ2=3.982; p=0.137 CYP2C9*3 (A1075C) А=0.96 С=0.04 А=0.95 С=0.05 А=0.96 С=0.04 χ2=0.427; p=0.808 VKORC 1173 С=0.31 Т=0.69 С=0.27 Т=0.73 С=0.28 Т=0.72 χ2=4.007; p=0.405 VKORC 1542 G=0.29 C=0.71 G=0.27 C=0.73 G=0.26 C=0.74 χ2=0.701; p=0.951 СYP4F2 G=0.64 A=0.36 G=0.72 A=0.28 G=0.73 A=0.27 χ2=6.175; p=0.186 GGCX C=0.95 G=0.05 C=0.97 G=0.03 C=0.98 G=0.02 χ2=0.968; p=0.616 CYP2D6*3 A=0.99 del=0.01 A=0.99 del=0.01 A=1.00 del=0.00 χ2=1.940; p=0.379 CYP2D6*4 G=0.94 A=0.06 G=0.90 A=0.10 G=0.91 A=0.09 χ2=2.417; p=0.299 CYP1A2*1F A=0.63 C=0.38 A=0.63 C=0.37 A=0.69 C=0.31 χ2=5.710; p=0.222

Table 7: Evaluation of allele and genotype frequency differences according to region (North, Northeast and South Kazakhstan).